TPO Recombinant Protein
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Product Specifications
CAS Number
9000-83-3
Synonyms
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
NCBI Gene ID
7124
UniProt
P40225
Accession Number
NP_000451.1
Accession Number mRNA
NM_000460.2
Gene Location
2p25
Host
E. coli
Origin Species
Human
Species Reactivity
Human
Sequence
Detection Range
The ED50 as determined by the dose-dependant stimulation of MO7e cells is < 1 ng/ml (1x106 units/mg).
Purity
> 98% by SDS-PAGE
Length
174
Form
Lyophilized
Molecular Weight
18.6 kDa
Shipping Conditions
Room Temperature
Frequently Asked Questions
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