TNFSF13B beta

BAFF (B cell activating factor) is a cytokine of the TNF superfamily and essential for the activation, differentiation and survival of B cells, produced predominantly by neutrophils, monocytes, macrophages and dendritic cells in mammals. Synonyms include TNFSF13B (tumor necrosis factor superfamily member 13B), BLyS (B lymphocyte stimulator), TALL-1, zTNF4[2] or CD257 antigen (cluster of differentiation 257) . It is a 285 amino acid long glycoprotein with glycosylation at site 124 and exists as a type 2 transmembrane protein. An isoform exists that lacks the membrane anchor and is therefore freely mobile in the cytosol. It is formed by post-translational modification and contains 152 amino acids.