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TNFSF10 (TRAIL)

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. Among TNF superfamily members, TRAIL is the most homologous to Fas Ligand, sharing 28% amino acid sequence identity in their extracellular domains. Human TRAIL shares 65% amino acid sequence identity with mouse TRAIL and is active on mouse cells.

Product Specifications

Synonyms

TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L

NCBI Gene ID

8743

UniProt

P50591

Accession Number

NP_00380.1

Accession Number mRNA

NM_003810.3

Chromosomal Location

3q26

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human TNFSF10

Clone

(#6D44)

Applications

N, IHC (P), FC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG1

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