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TNFRSF17 (BCMA)

B cell maturation protein (BCMA) is a member of the TNF receptor superfamily (TNFRSF17) . BCMA is expressed in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. BCMA binding to APRIL or BAFF stimulates IgM production in peripheral blood B cells and increases the survival of cultured B cells. Mature human and mouse BCMA share 86% amino acid sequence identity.

Product Specifications

Synonyms

TNFRSF17; BCM; BCMA; CD269

NCBI Gene ID

608

UniProt

Q02223

Accession Number

NP_001183.2

Accession Number mRNA

NM_001192.2

Chromosomal Location

16p13.1

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human TNFRSF17 EC domain

Clone

(#3D44)

Applications

WB, Blocking

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG2

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