TNFRSF1A

Tumor Necrosis Factor Receptor-I (TNF RI, also known as p55/p60) is a high affinity receptor for TNF-alpha and -beta, potent mediators of multiple aspects of inflammatory immune responses. TNF RI, along with TNF RII, is a prototypic member of the TNF receptor superfamily and has been designated TNFRSF1 (A) . All cell types are thought to express TNF RI, and most of the biological functions of TNF are mediated via TNF RI. Soluble forms of both TNF RI, generated as a result of proteolytic cleavage of the extracellular domain, has been detected in vivo in various biological fluids. The soluble TNF RI receptor can bind TNF with high affinity and functions as a TNF antagonist. TNF RI is thought to form homotrimers or oligomers upon ligand binding. The TNF RI extracellular domain includes four cysteine-rich repeats characteristic of the TNF receptor superfamily. TNF RI is capable of interacting with adaptor proteins upstream of NF-kB activation and contains a cytoplasmic "death domain" upstream of caspase-dependent apoptosis cascades.