TL-1A (Animal Free)
TL‐1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in the placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL‐1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF‐κB activation, caspase activity, and apoptosis in responding cell lines. TL‐1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant Human TL‐1A is a 22.1 kDa polypeptide of 195 amino acid residues.
Product Specifications
Synonyms
TNFSF15; TL1; TL1A; VEGI; VEGI192A
NCBI Gene ID
9966
UniProt
O95150
Accession Number
NP_005109
Accession Number mRNA
NM_005118
Chromosomal Location
9q32
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to stimulate IFN-γ production by human PBMC co-stimulated with Human IL-12 and Human IL-18.
Length
194
Form
Lyophilized
Molecular Weight
22 kDa
Host or Source
E. coli
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