TIMP-1
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Product Specifications
Synonyms
TIMP1; EPA; EPO; HCI; CLGI; TIMP
NCBI Gene ID
7076
UniProt
P01033
Accession Number
NP_003245
Accession Number mRNA
NM_003254
Chromosomal Location
Xp11.3-p11.23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant TIMP-1 protein
Clone
(#4A16)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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