SNCA
The synuclein family (SNCA) includes synuclein-alpha, -beta, and -gamma, and synoretin. These small, highly conserved proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Synuclein-alpha is normally a soluble protein. Abnormal synuclein-alpha forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. Synucleins beta and gamma (synoretin) associate with synuclein-alpha and inhibit its aggregation.
Product Specifications
Synonyms
SNCA; PD1; NACP; PARK1; PARK4
NCBI Gene ID
6622
UniProt
P37840
Accession Number
NP_000336.1
Accession Number mRNA
NM_000345.3
Chromosomal Location
4q21
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human SNCA
Clone
(#7D53)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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