SDF-1 beta (CXCL12)
SDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant rat SDF-1β is an 8.4 kDa protein containing 72 amino acid residues.
Product Specifications
Synonyms
Cxcl12; Sdf1
NCBI Gene ID
24772
UniProt
Q9QZD1
Accession Number
NP_071513.1
Accession Number mRNA
NM_022177.3
Chromosomal Location
4q42.1
Reactivity
Rat
Cross Reactivity
Human
Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNKRL KM
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 100.0-200.0 ng/ml.
Length
72
Form
Lyophilized
Molecular Weight
8.4 kDa
Host or Source
E. coli
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