Sclerostin

SOST, also known as sclerostin, is a member of the Cerberus/DAN family of BMP antagonists, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones.

Product Specifications

Synonyms

Sost; 5430411E23Rik

NCBI Gene ID

74499

UniProt

Q99P68

Accession Number

NP_077769.3

Accession Number mRNA

NM_024449.5

Chromosomal Location

11 D; 11

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Mouse recombinant protein of Sclerostin

Clone

(#4D77)

Applications

Purification Method

Protein A/G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.