RANTES

RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Product Specifications

Synonyms

CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E

NCBI Gene ID

6352

UniProt

P13501

Accession Number

NP_002976.2

Accession Number mRNA

NM_002985

Chromosomal Location

17q11.2-q12

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant Human RANTES (CCL5)

Applications

ELISA, N, WB, IHC

Purification Method

Protein A chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Form

Lyophilized from PBS

Buffer

PBS

Reconstitution

Water

Storage Conditions

The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.