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Protein S

Das Protein S (S für Seattle) ist ein Vitamin-K-abhängiges Plasma-Glykoprotein, welches u. a. in der Leber gebildet wird. Es wirkt der Entstehung von Blutgerinnseln (Thromben) entgegen und steigert zudem deren Auflösung (Fibrinolyse) . Protein S ist eine Plasma-Serin-Protease, welche beim Menschen in den Leberzellen, im Endothel und anderen Gewebe gebildet wird. Dieser Vorgang ist Vitamin-K-abhängig. Das Protein S wirkt als Kofaktor von Protein C, welches die Gerinnungsfaktoren Va, sowie VIIIa inaktiviert und abbaut. Dies bremst das Ablaufen der normalen Blutgerinnung. Des Weiteren unterstützt Protein S die Phagozytose von apoptotischen Zellen und spielt auch eine Rolle beim Ablauf von Entzündungsvorgängen.

Product Specifications

Synonyms

PROS; PROS1; protein S (alpha) ; Protein S; protein Sa; PS21; PS22; PS23; PS24; PS25; PSA; vitamin K-dependent plasma protein S; vitamin K-dependent protein S

NCBI Gene ID

19128

UniProt

Q08761

Accession Number

NP_035303.1

Accession Number mRNA

NM_011173.3

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant Mouse Protein S

Clone

(#17R3)

Applications

WB

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG2

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