Presenilin-1
Presenilin1 (PS1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N- and C- terminal fragments. Some mutations in PS 1 are associated with the risk of early onset familial Alzheimer's disease.
Product Specifications
Synonyms
PSEN1; AD3; FAD; PS1; PS-1; S182
NCBI Gene ID
5663
UniProt
P49768
Accession Number
NP_015557.2
Accession Number mRNA
NM_007318.2
Chromosomal Location
14q24.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Presenilin-1
Clone
(#7G6)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2
Frequently Asked Questions
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