PlGF
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra and interchain disulfides are conserved among these growth factors. As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF1, PlGF2 and PlGF3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. In normal mouse tissues, only one mouse PlGF mRNA encoding the equivalent of human PlGF2 has been identified. Mouse PlGF shares 65% amino acid identity with human PlGF2. The gene for PlGF has been mapped to mouse chromosome 12 and human chromosome 14. PlGF binds with high affinity to Flt1, but not to Flk1/KDR.
Product Specifications
Synonyms
Pgf; PlGF; Plgf; AI854365
NCBI Gene ID
18654
UniProt
P49764
Accession Number
NP_032853
Accession Number mRNA
NM_008827
Chromosomal Location
12 D; 12 39.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
ALSAGNNSTEVEVVPFNEVWGRSYCRPMEKLVYILDEYPDEVSHIFSPSCVLLSRCSGCCGDEGLHCVPIKTANITMQILKIPPNRDPHFYVEMTFSQDVLCECRPILETTKAERRKTKGKRKRSRNSQTEEPHP
Assay Protocol
Purity
> 95% by SDS-PAGE
Bioactivity
Length
135/132
Form
Lyophilized
Buffer
25 mM Tris, 75 mM NaCl pH 8.5
Additives
BSA (50-fold)
Reconstitution
50 mM acetic acid
Molecular Weight
~40 kDa
Storage Conditions
The lyophilized mouse PIGF, though stable at room temperature, is best stored in working aliquots at -20°C to -70°C.
Host or Source
Insect cells
N Terminal Sequence
ALSAGNNSTE and AGNNSTE
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