PIN
Pin1 is a peptidylprolyl isomerase (PPI) that targets phosphorylated Ser or Thr residues followed by a Pro (S/TP) . Isomerization of phosphorylated Ser or Thr residues may alter protein confirmation and, subsequently, modify activity. Pin1 is overexpressed in many human breast cancers, and has been shown to modify numerous proteins including p53, NFκB, cJun, cyclin D1, and βcatenin.
Product Specifications
Synonyms
PIN1; DOD; UBL5
NCBI Gene ID
5300
UniProt
Q13526
Accession Number
NP_006212.1
Accession Number mRNA
NM_006221.3
Chromosomal Location
19p13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human PIN
Clone
(#9S2)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1
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