NT-3
Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive NT-3 is predicted to be a noncovalently linked homodimer.
Product Specifications
Synonyms
NTF3; NT3; HDNF; NGF2; NGF-2
NCBI Gene ID
4908
UniProt
P20783
Accession Number
NP_001096124.1
Accession Number mRNA
NM_001102654
Chromosomal Location
12p13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human NT-3
Clone
(#8F34)
Applications
N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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