NKp46
NKp30/NCR3, NKp44/NCR2, and NKp46/NCR1 are termed natural cytotoxicity receptors (NCR) . These receptors are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp44 is induced upon activation of resting NK cells with IL-2 and can bind to viral hemagglutinins. NK-mediated dendritic cell (DC) recognition is highly dependent on engagement of NKp30 and may result in lysis of the DC.
Product Specifications
Synonyms
NCR1; LY94; CD335; NKP46; NK-p46
NCBI Gene ID
9437
UniProt
O76036
Accession Number
NP_004820.1
Accession Number mRNA
NM_004829.6
Chromosomal Location
19q13.42
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human NKp46
Clone
(#8F24)
Applications
WB, IHC (F), FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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