NKG2D
NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell subsets, where it functions as an activating receptor to trigger cytolytic activity and cytokine secretion. Ligands for human NKG2D include MICA, MICB, and ULBP-1, -2, -3, and -4. Mouse NKG2D ligands include H60, MULT-1, and Rae-1 alpha, beta, gamma, delta, and epsilon.
Product Specifications
Synonyms
Klrk1; Nkg2d; NKG2-D; D6H12S2489E
NCBI Gene ID
27007
UniProt
O54709
Accession Number
NP_149069.1
Accession Number mRNA
NM_033078.3
Chromosomal Location
6 F3; 6 62.53 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse NKG2D
Clone
(#4J50)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
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