NKG2D

NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell subsets, where it functions as an activating receptor to trigger cytolytic activity and cytokine secretion. Ligands for human NKG2D include MICA, MICB, and ULBP-1, -2, -3, and -4. Mouse NKG2D ligands include H60, MULT-1, and Rae-1 alpha, beta, gamma, delta, and epsilon.

Product Specifications

Synonyms

KLRK1; KLR; CD314; NKG2D; NKG2-D; D12S2489E

NCBI Gene ID

22914

UniProt

P26718

Accession Number

NP_031386.2

Accession Number mRNA

NM_007360.3

Chromosomal Location

12p13.2-p12.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human NKG2D

Clone

(#10R27)

Applications

WB, FC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.