NKG2A
NKG2A and NKG2C are type II transmembrane proteins with extracellular C-type lectin domains. These proteins heterodimerize with CD94 to form complexes that recognize HLA-E as ligand. The NKG2A/CD94 complex delivers an inhibitory signal resulting from ITIMs within the NKG2A cytoplasmic domain. NKG2C/CD94 provides an activating signal due to association with the ITAM-containing DAP12 adapter protein. These complexes are expressed on NK and T cell subsets.
Product Specifications
Synonyms
KLRC1; NKG2; NKG2A; CD159A
NCBI Gene ID
3821
UniProt
P26715
Accession Number
NP_002250.1
Accession Number mRNA
NM_002259.4
Chromosomal Location
12p13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human NKG2A
Clone
(#8S36)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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