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NKG2A

NKG2A and NKG2C are type II transmembrane proteins with extracellular C-type lectin domains. These proteins heterodimerize with CD94 to form complexes that recognize HLA-E as ligand. The NKG2A/CD94 complex delivers an inhibitory signal resulting from ITIMs within the NKG2A cytoplasmic domain. NKG2C/CD94 provides an activating signal due to association with the ITAM-containing DAP12 adapter protein. These complexes are expressed on NK and T cell subsets.

Product Specifications

Synonyms

KLRC1; NKG2; NKG2A; CD159A

NCBI Gene ID

3821

UniProt

P26715

Accession Number

NP_002250.1

Accession Number mRNA

NM_002259.4

Chromosomal Location

12p13

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human NKG2A

Clone

(#8S36)

Applications

WB

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

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