NGF-beta
Β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues) . The three disulfide bonds are required for biological activity.
Product Specifications
Synonyms
NGF; NGFB; HSAN5; Beta-NGF
NCBI Gene ID
4803
UniProt
P01138
Accession Number
NP_002497.2
Accession Number mRNA
NM_002506
Chromosomal Location
1p13.1
Reactivity
Human
Cross Reactivity
Chicken, Hamster, Mouse, Rat, Human, Leech
Sequence
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Bioactivity
Length
240
Form
Lyophilized
Molecular Weight
13.5 kDa
Host or Source
E. coli
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