NCAM-L1

The cell adhesion molecule NCAM-L1 (or L1CAM) is an immunoglobulin superfamily adhesion molecule that is critical for neural development. Two alternatively spliced isoforms of L1CAM have been described. The full-length signaling isoform is expressed exclusively in neurons. The second non-neuronal variant lacks a five-residue extracellular sequence and a four residue cytoplasmic sequence that is important in signaling and clathrin-mediated endocytosis.

Product Specifications

Synonyms

L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1

NCBI Gene ID

3897

UniProt

P32004

Accession Number

NP_000416.1

Accession Number mRNA

NM_000425.4

Chromosomal Location

Xq28

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant protein of NCAM-L1 EC domain

Clone

(#1J36)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.