MMP-14
As the first member of membrane type (MT) MMPs, MMP-14, also known as MT1MMP, plays an important role in extracellular matrix (ECM) remodeling by being able to degrade type I collagen, activate pro MMP2 and process cell adhesion molecules such as CD44 and integrin αV. MMP-14 is therefore a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. Structurally, MMP14 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. Recombinant Human MMP-14 consists of the pro and catalytic domains, which can be activated by treatment with furin.
Product Specifications
Synonyms
MMP14; 1; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1
NCBI Gene ID
4323
UniProt
P50281
Accession Number
NP_004986.1
Accession Number mRNA
NM_004995.2
Chromosomal Location
14q11-q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-14
Clone
(#9E57)
Applications
WB, IHC (P), FC, Detection Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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