MIP-3 beta (CCL19)
MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Mouse urine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
Ccl19; ELC; CKb11; MIP3B; Scya19; exodus-3
NCBI Gene ID
24047
UniProt
O70460
Accession Number
NP_036018.1
Accession Number mRNA
NM_011888
Chromosomal Location
4 A5; 4
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Monkey, Leech, Rat
Sequence
GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human mature dendritic cells using a concentration range of 10.0-100.0 ng/ml.
Length
83
Form
Lyophilized
Molecular Weight
9.2 kDa
Host or Source
E. coli
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