MIP-3 beta (CCL19)
MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19
NCBI Gene ID
6363
UniProt
Q99731
Accession Number
NP_006265
Accession Number mRNA
NM_006274
Chromosomal Location
9p13
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human, Leech, Bacteria
Sequence
GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml.
Length
77
Form
Lyophilized
Molecular Weight
8.8 kDa
Host or Source
E. coli
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