MIP-3 alpha (CCL20)
MIP-3 alpha is a CC chemokine that is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 alpha is an 8.0 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; MIP-3-alpha
NCBI Gene ID
6363
UniProt
P78556
Accession Number
NP_004582.1
Accession Number mRNA
NM_004591
Chromosomal Location
9p13
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml.
Length
70
Form
Lyophilized
Molecular Weight
8.0 kDa
Host or Source
E. coli
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