MIP-2 (CXCL2, Gro-beta)
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant mouse MIP-2 is a 7.8 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Product Specifications
Synonyms
Cxcl2; GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a
NCBI Gene ID
20310
UniProt
P10889
Accession Number
NP_033166.1
Accession Number mRNA
NM_009140.2
Chromosomal Location
5 E1; 5 51.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml.
Length
73
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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