Midkine
Midkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK) . MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.
Product Specifications
Synonyms
MDK; MK; NEGF2
NCBI Gene ID
4192
UniProt
P21741
Accession Number
NP_001012333
Accession Number mRNA
NM_001012333
Chromosomal Location
11p11.2
Reactivity
Human
Cross Reactivity
Mouse, Pig, Shark, Human, Hagfish, Squid
Sequence
VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.
Length
123
Form
Lyophilized
Buffer
0.4x PBS, pH 7.4
Reconstitution
Water
Molecular Weight
13.4 kDa
Storage Conditions
Host or Source
E. coli
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