M-CSF
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Product Specifications
Synonyms
Csf1; op; Csfm; MCSF; C87615
NCBI Gene ID
12977
UniProt
P07141
Accession Number
NP_031804.3
Accession Number mRNA
NM_007778
Chromosomal Location
3 F3; 3 51.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse, Human, Rat
Sequence
Assay Protocol
Purity
> 98% by SDS-PAGE
Bioactivity
The biological activity was determined by the induction of proliferation in the NFS 60 cell line.
Length
156
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
36.4 kDa
Storage Conditions
Host or Source
E. coli
N Terminal Sequence
MKEVS
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