MCP-5 (CCL12)
MCP-5 or CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid sequence identity in the mature protein) . Mouse MCP-5 encodes a 104 amino acid residue precursor protein with a 22 aa residue predicted hydrophobic signal sequence that is cleaved to generate a 82 aa residue mature protein. MCP-5 is expressed constitutively in the thymus and lymph nodes. Under inflammatory conditions, its expression is also induced in activated macrophages and mast cells. The gene for mouse MCP1 has been mapped to the CC chemokine cluster on chromosome 11. Recombinant MCP-5 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, MCP-5 will also chemoattract eosinophils. MCP-5 has been found to be a functional ligand for CCR2 but not CCR1, CCR3 or CCR5.
Product Specifications
Synonyms
Cma1; Mcp5; Mcp-5; Mcpt5; MMCP-5
NCBI Gene ID
17228
UniProt
P21844
Accession Number
NP_034910.1
Accession Number mRNA
NM_010780.2
Chromosomal Location
14 C3; 14 20.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Bacteria
Sequence
GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.
Length
82
Form
Lyophilized
Molecular Weight
9.3 kDa
Host or Source
E. coli
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