MCP-2 (CCL8)
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-2 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
Ccl8; HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik
NCBI Gene ID
20307
UniProt
Q9Z121
Accession Number
NP_067418.1
Accession Number mRNA
NM_021443
Chromosomal Location
11 C; 11 47.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Bacteria
Sequence
GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.
Length
74
Form
Lyophilized
Molecular Weight
8.5 kDa
Host or Source
E. coli
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