Lyve-1
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Product Specifications
Synonyms
LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1
NCBI Gene ID
10894
UniProt
Q9Y5Y7
Accession Number
NP_006682
Accession Number mRNA
NM_006691
Chromosomal Location
11p15
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant LYVE-1
Clone
(#7F13)
Applications
WB, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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