Lymphotoxin alpha
Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.
Product Specifications
Synonyms
LTA; LT; TNFB; TNFSF1
NCBI Gene ID
4049
UniProt
P01374
Accession Number
NP_001153212.1
Accession Number mRNA
NM_001159740.1
Chromosomal Location
6p21.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Lymphotoxin alpha/beta
Clone
(#12B4)
Applications
N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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