Lymphotoxin alpha

Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.

Product Specifications

Synonyms

LTA; LT; TNFB; TNFSF1

NCBI Gene ID

4049

UniProt

P01374

Accession Number

NP_001153212.1

Accession Number mRNA

NM_001159740.1

Chromosomal Location

6p21.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human Lymphotoxin alpha/beta

Clone

(#12B4)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.