LIX/CXCL6 (92 aa)
LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 9.8 kDa protein containing 93 amino acid residues.
Product Specifications
Synonyms
Cxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
NCBI Gene ID
20311
UniProt
P50228
Accession Number
NP_033167.2
Accession Number mRNA
NM_009141.2
Chromosomal Location
5 E1; 5 53.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.
Length
93
Form
Lyophilized
Molecular Weight
9.8 kDa
Host or Source
E. coli
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