LIGHT (Animal Free)
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain.
Product Specifications
Synonyms
Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L; LIGHT; tumor necrosis factor (ligand) superfamily, member 14
NCBI Gene ID
50930
UniProt
Q9QYH9
Accession Number
NP_062291
Accession Number mRNA
NM_019418
Chromosomal Location
17; 17 D-E1
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Not available.
Length
183
Form
Lyophilized
Molecular Weight
20.1 kDa
Host or Source
E. coli
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