LEC/NCC-4 (CCL16)
LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
CCL16; LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16
NCBI Gene ID
6360
UniProt
O15467
Accession Number
NP_004581.1
Accession Number mRNA
NM_004590.2
Chromosomal Location
17q11.2
Reactivity
Human
Cross Reactivity
Mouse, Human, Bacteria
Sequence
QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKALNCHLP AIIFVTKRNR EVCTNPNDDW VQEYIKDPNL PLLPTRNLST VKIITAKNGQ PQLLNSQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract total human monocytes using a concentration range of 10-100 ng/ml.
Length
97
Form
Lyophilized
Molecular Weight
11.2 kDa
Host or Source
E. coli
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