Kremen-1
Kremen (Kringle-containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Two related members, Kremen-1 and -2, have been identified. Kremens bind a subset of the secreted Dickkopf (Dkk) proteins with high affinity. The canonical Wnt signaling pathway receptor complex composed of Wnt, the seven-transmembrane domain receptor Frizzled, and the receptor-related protein 5/6 (LRP5/6) coreceptor, is modulated by Kremens and Dkk proteins.
Product Specifications
Synonyms
Kremen1; Krm1; Kremen; AV002070
NCBI Gene ID
84035
UniProt
Q99N43
Accession Number
NP_115772.2
Accession Number mRNA
NM_032396.3
Chromosomal Location
11 A1; 11
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant EC domain of Kremen-1
Clone
(#6K45)
Applications
WB
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
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