Jagged-1
JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 (cluster of differentiation 339) . The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Product Specifications
Synonyms
JAG1; AGS; AHD; AWS; HJ1; CD339; JAGL1
NCBI Gene ID
182
UniProt
P78504
Accession Number
NP_000205.1
Accession Number mRNA
NM_000214.2
Chromosomal Location
20p12.1-p11.23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Jagged-1
Clone
(#4A24)
Applications
WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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