Jagged-1

JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 (cluster of differentiation 339) . The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Product Specifications

Synonyms

JAG1; AGS; AHD; AWS; HJ1; CD339; JAGL1

NCBI Gene ID

182

UniProt

P78504

Accession Number

NP_000205.1

Accession Number mRNA

NM_000214.2

Chromosomal Location

20p12.1-p11.23

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human Jagged-1

Clone

(#4A24)

Applications

WB, FC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.