I-TAC (CXCL11)
I-TAC is a "non-ELR" CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. Recombinant murine I-TAC is a 9.0 kDa protein containing 79 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.
Product Specifications
Synonyms
CXCL11
NCBI Gene ID
56066
UniProt
Q9JHH5
Accession Number
NP_062367.1
Accession Number mRNA
NM_019494.1
Chromosomal Location
5; 5 E3
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Monkey, Bacteria
Sequence
FLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract murine CXCR3 transfected HEK/293 cells using a concentration range of 10.0-100.0 ng/ml.
Length
79
Form
Lyophilized
Molecular Weight
9.0 kDa
Host or Source
E. coli
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