IP-10 (CXCL10)
IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant rat IP-10 is an 8.6 kDa protein consisting of 77 amino acids including the four conserved cysteine residues present in CXC chemokines.
Product Specifications
Synonyms
Gamma-Interferon inducible protein 10, CXCL10, crg-2
NCBI Gene ID
245920
UniProt
P48973
Accession Number
NP_620789.1
Accession Number mRNA
NM_139089.1
Chromosomal Location
14p22
Reactivity
Rat
Cross Reactivity
Rat, Human
Sequence
IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.
Length
77
Form
Lyophilized
Molecular Weight
8.6 kDa
Host or Source
E. coli
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