IP-10 (CXCL10)
IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant human IP-10 is an 8.6 kDa protein consisting of 77 amino acids including the four conserved cysteine residues present in CXC chemokines.
Product Specifications
Synonyms
CXCL10
NCBI Gene ID
3627
UniProt
P02778
Accession Number
NP_001556.2
Accession Number mRNA
NM_001565.3
Chromosomal Location
4q21
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Leech, Human
Sequence
VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.
Length
77
Form
Lyophilized
Molecular Weight
8.6 kDa
Host or Source
E. coli
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