IL-33
IL-33 is a proinflammatory protein that may also regulate gene transcription. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines and is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1alpha or IL-1 beta stimulation. Similar to IL-1, IL-33 can be cleaved in vitro by caspase-1, generating an N-terminal fragment that is slightly shorter than the C-terminal fragment. The N-terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain.
Product Specifications
Synonyms
IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2
NCBI Gene ID
90865
UniProt
O95760
Accession Number
NP_254274
Accession Number mRNA
NM_033439
Chromosomal Location
9p24.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-33
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
Host or Source
Rabbit
Frequently Asked Questions
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