IL-33
Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.
Product Specifications
Synonyms
IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2
NCBI Gene ID
90865
UniProt
O95760
Accession Number
NP_254274
Accession Number mRNA
NM_033439
Chromosomal Location
9p24.1
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
SITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.
Length
159
Form
Lyophilized
Molecular Weight
17.9 kDa
Host or Source
E. coli
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