IL-24
IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
Product Specifications
Synonyms
Interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B
NCBI Gene ID
11009
UniProt
Q13007
Accession Number
NP_006841.1
Accession Number mRNA
NM_006850.3
Chromosomal Location
1q32
Reactivity
Human
Cross Reactivity
Human
Label
His-tag
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Testing in progress.
Length
161
Form
Lyophilized
Molecular Weight
18.9 kDa
Host or Source
CHO cells
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