IL-23
IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17 mediated responses. Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids) .
Product Specifications
Synonyms
IL-23
NCBI Gene ID
51561
UniProt
Q9NPF7
Accession Number
NP_057668.1
Accession Number mRNA
NM_016584.2
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to stimulate the proliferation of HEK-BlueTM-IL-23 reporter cells.
Length
476
Form
Lyophilized
Molecular Weight
53.5 kDa
Host or Source
Insect cells
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