IL-22

IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 3-34 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Product Specifications

Synonyms

IL22; IL-22; Iltif; IL-22a; ILTIFa

NCBI Gene ID

50929

UniProt

Q9JJY9

Accession Number

NP_058667.1

Accession Number mRNA

NM_016971

Chromosomal Location

10 D2; 10 67.0 cM

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant mouse IL-22

Clone

Rabbit IgG

Applications

ELISA, WB

Purification Method

Antigen-affinity purified

Assay Protocol

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Form

Lyophilized from PBS

Buffer

PBS

Reconstitution

Water

Storage Conditions

The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.