IL-22 receptor antagonist (Y51A), pegylated
Mono-pegylated (with 20 kDa PEG) recombinant mouse interleukin 22 Y51A mutant (numbering according to human IL-22 including signal peptide) is one polypeptide chain containing 147 amino, an additional Ala at N-terminus and one molecule of PEG 20 kDa at its N-terminus, having an expected molecular mass of ~ 36 kDa as determined by MS. However due to enlarged hydrodymanic volume it runs on the SDS-PAGE as 50 kDa protein and in gel-filtration on Superdex 200 as over 200 kDa protein. For more details see L. Niv-Spector et al. Protein Eng Des Sel. (PEDS) 25:397-404 (2012) .
Product Specifications
Synonyms
IL22; IL-22; Iltif; IL-22a; ILTIFa
NCBI Gene ID
50929
UniProt
Q9JJY9
Accession Number
NP_058667.1
Accession Number mRNA
NM_016971
Reactivity
Mouse
Cross Reactivity
Mouse
Label
PEG
Sequence
ALPVNTRCKLEVSNFQQPAIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGEIKAIGELDLLFMSLRNACV
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98.0% as determined by Gel filtration and SDS-PAGE gel.
Bioactivity
Length
147
Form
Lyophilized
Reconstitution
Water
Molecular Weight
16.7 kDa
Host or Source
E. coli
N Terminal Sequence
ALPVN
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