IL-17D
IL‐17D is a disulfide‐linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17D has the ability to stimulate the production of IL‐6, IL‐8 and GM‐CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony‐forming assays. Recombinant Murine IL-17D is a 40.6 kDa, disulfide-linked homodimer of two 183 amino acid, polypeptide chains.
Product Specifications
Synonyms
Interleukin-17D
NCBI Gene ID
239114
UniProt
Q8K4C4
Accession Number
NP_665836.2
Accession Number mRNA
NM_145837.3
Chromosomal Location
14; 14 C3
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to bind murine IL-17RB Fc Chimera in a functional ELISA.
Length
183
Form
Lyophilized
Molecular Weight
40.6 kDa
Host or Source
E.coli
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