IL-17B
IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.
Product Specifications
Synonyms
IL17B; NIRF; IL-20; IL-17B; ZCYTO7
NCBI Gene ID
27190
UniProt
Q9UHF5
Accession Number
NP_055258.1
Accession Number mRNA
NM_014443
Chromosomal Location
5q33.1
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.
Length
161
Form
Lyophilized
Molecular Weight
36.6 kDa
Host or Source
E. coli
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